Correlation study of 25-hydroxy vitamin D3 levels of patients with type 2 diabetes mellitus and insulin secretion in early phase
10.13699/j.cnki.1001-6821.2015.24.013
- VernacularTitle:2型糖尿病患者血清25－羟维生素 D3水平与胰岛素早相分泌的相关性分析
- Author:
Ming-Xia LI
1
;
Yi-Feng ZHAO
;
Li-Juan ZUO
;
Li SHI
;
Wei-Dong REN
;
Zhi-Ying ZHANG
;
Jun GU
;
Zheng-Rong XU
Author Information
1. 河北北方学院 附属第一医院 内分泌科
- Keywords:
type 2 diabetes;
25-hydroxy vitamin D3;
early phase insulin secretion;
insulin resistance;
relevance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(24):2411-2413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum 25-hydroxy vitamin D3 level and insulin secretion in type 2 diabetes mellitus patients.Methods A total of 96 type 2 diabetes patients were selected as the treatment group and 96 healthy volunteers as the control group. The 25-hydroxy vitamin D3 levels in 2 groups were compared with the main clinical indicators.And the correlation between 25-hydroxy vita-min D3 levels and body mass index, glycosylated hemoglobin, islet βcell function index, islet resistance index, fasting insulin and peak ratio were analyzed.Results The serum 25-hydroxy vitamin D3 levels in the treatment group were significantly lower than those in the control group ( P <0.05 ) .Fasting blood glucose, glycosylated hemoglobin, fasting insulin, islet βcell function index, peak ratio and islet resis-tance index were significantly higher in the treatment group than in the control group ( P<0.05 ) .Serum 25-hydroxy vitamin D3 level wsa nega-tively correlated with body mass index, glycosylated hemoglobin and islet resistance index (P<0.05), while it was positively correlated with the isletβcell function index and peak ratio(P<0.05).Conclusion There is a lack of vitamin D in type 2 diabetes patients, which may be one of the rea-sons leading to the decrease of insulin secretion in type 2 diabetic patients.
