Clinical efficacy of montelukast sodium in the treatment of chronic obstructive pulmonary disease combined with obstructive sleep disordered breathing overlap syndrome
10.13699/j.cnki.1001-6821.2015.24.009
- VernacularTitle:孟鲁司特钠对慢性阻塞性肺疾病合并阻塞性睡眠呼吸障碍重叠综合征的临床研究
- Author:
Gui-Yuan JIANG
1
;
Xin-Nian LIU
;
Cai-Xia ZHANG
;
Chun-Yan HUANG
Author Information
1. 厦门长庚医院 呼吸科
- Keywords:
montelukast;
Bi-level positive airway pressure( BiPAP);
overlap syndrome;
polysomnography
- From:
The Chinese Journal of Clinical Pharmacology
2015;(24):2399-2401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of montelukast sodium combined with Bi-level positive airway pressure ( BiPAP) respi-rator in treatment of chronic obstructive pulmonary disease combined with obstructive sleep disordered breathing overlap syndrome.Methods A total of 103 patients with overlap syndrome were divided into treatment group(n=51) and control group(n=52).Patients in treatment group were received montelukast sodium combined with BiPAP respirator, while patients in control group received BiPAP respiratoronly.All patients were treated for 4 weeks.The clinical symptom score, C -reactive protein ( CRP ) , arterial blood gas analysis parameters and pulmonary function parameters were recorded before and after therapy in two groups were ob-served.Results The level of CRP after therapy was significantly lower in two groups than before therapy ( P <0.05 ) , treatment group lower than control group(P<0.05).After therapy, the levels of apnea hypop-nea index ( AHI) ,partial pressure of carbon dioxide( PaCO2 ) were signif-icantly lowerthan before therapy ( P<0.05 );andpartial pressure of oxy-gen ( PaO2 ) , forced expiratory volume in one second ( FEV1 ) and FEV1 /( forced vital capacity, FVC ) were significantly higher than before therapy ( P<0.05).Conclusion Montelukast sodium combined with BiPAP respirator had a good effect in overlap syndrome patients.
