Progress of the cardioprotective role of nuclear factor erythroid 2-related factor 2 in myocardial ischemia reperfusion injury
10.13699/j.cnki.1001-6821.2015.23.029
- VernacularTitle:核因子 E2相关因子2对心肌缺血再灌注损伤的保护作用研究进展
- Author:
Zhao-Hui GUO
1
;
Miao YAN
;
Bi-Kui ZHANG
Author Information
1. 中南大学 湘雅二医院 药学部
- Keywords:
nuclear factor erythroid 2 -related factor 2;
myocardial ischemia reperfusion injury;
oxidative stress;
protection
- From:
The Chinese Journal of Clinical Pharmacology
2015;(23):2366-2369
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor erythroid 2 -related factor 2 ( Nrf2 ) is a key transcriptional factor of endogenous antioxidant defense system, which maintains the redox balance by mediating Nrf2/ARE pathways that could regulate the expression of a battery of downstream antioxidant enzymes, phase Ⅱdetoxifying enzymes and transport proteins.Recent studies have demonstrated that Nrf2 plays a significant role in the pathogenesis of myo-cardial ischemia reperfusion injury ( MIRI) , thus activation of Nrf2 lead to the increase of antioxidant capacity, and eventually alleviates myocar-dial injury as well as exerts cardioprotection effect to some extent, which makes it a novel promising therapeutic target.Therefore, this paper re-views the research progress of the cardioprotection effect of Nrf2 in MIRI, attempting to provide innovative ideas about treatment for MIRI in clinical practice.
