Study and prevention of NDM-1-producing superbug
10.13699/j.cnki.1001-6821.2015.23.028
- VernacularTitle:新德里金属β内酰胺酶－1型超级细菌的研究及防控
- Author:
Wei-Mei OU
1
;
LüYuan
Author Information
1. 北京大学 第一医院 临床药理研究所
- Keywords:
superbug;
New Delhi metallo-β-lactamase 1;
metallo-β-lactamase;
carbapenem
- From:
The Chinese Journal of Clinical Pharmacology
2015;(23):2362-2365
- CountryChina
- Language:Chinese
-
Abstract:
New Delhi metallo-β-lactamase 1 ( NDM-1 ) belongs to B1 subgroup of metallo-β-lactamase.It can hydrolyze almost all β-lactam antimicrobials (except aztreonam).Most of blaNDM-1 gene was on plasmids, which can easily result in horizontal transmission.There are mainly three ways for human to acquire NDM-1 -producing bacteria, which are nosocomial infection, personal travel and community acquisi-tion.The detection methods of NDM-1 are phenotype screening, pheno-type confirmation and gene confirmation. This review summarized the epidemiology, molecular -biological characteristics, detection methods and prevention measures of NDM -1 -producing bacteria, aiming at enhancing the recognization, prevention and control of NDM -1 -producing superbug.
