Clinical effect of meloxicam combined with alendronate in the treatment of knee osteoarthritis with osteoporosis
10.13699/j.cnki.1001-6821.2015.23.006
- VernacularTitle:美洛昔康联合阿仑膦酸钠对膝骨性关节炎合并骨质疏松的临床研究
- Author:
Wei-Qi WANG
1
;
Xuan-Liang RU
;
Chun LIU
Author Information
1. 浙江医院骨科
- Keywords:
nonsteroidal antiinflammatory drugs ( NSAIDs );
bisphos-phonates;
knee osteoarthritis;
pain
- From:
The Chinese Journal of Clinical Pharmacology
2015;(23):2297-2299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of meloxicam and alendronate in the treatment of knee osteoarthritis with osteoporosis. Methods A total of 64 cases of Kellgren-Lawrence grade 2-3 of knee osteoarthritis with osteoporosis patients were randomly divided into treat-ment group and control group.Treatment group was treated with meloxi-cam 15 mg, three times a day for three months, and alemdronate 70 mg, once three day for one month.Control group was treated with meloxicam only.The clinical effect, pain, stiff degree, daily activities difficulty and quality of life of the two groups were compared.Results After treat-ment, total effective rate of treatment group was 96.9%, significantly higher than 78.1% in control group ( P <0.05 ) .The pain degree in treatment group after treatment significantly decreased than that before treatment ( P<0.05).The degree of stiffness, difficulty of daily activi-ties and the changes in quality of life were significantly better than those of control group ( P <0.05 ) .Conclusion Meloxicam combined with alendronate in the treatment of knee osteoarthritis with osteoporosis can not only significantly reduce the pain, improve the stiff degree, but also improve the quality of life in early treatment of knee osteoarthritis.
