Clinical efficacy and mechanism of alteplase combined with butylphthalide sodium chloride on patients with acute cerebral infarction
10.13699/j.cnki.1001-6821.2015.23.005
- VernacularTitle:阿替普酶联合丁苯酞对急性脑梗死的临床疗效及作用机制研究
- Author:
Chao-Chan CHENG
1
;
Han-Ming TU
;
Ai-Juan YING
;
Guo-Qiang XU
;
Ling-Zhi HU
;
Jun-Zhi PAN
Author Information
1. 永康市第一人民医院 神经内科
- Keywords:
alteplase;
butylphthalide and sodium chloride;
acute cerebral infarction;
stress factor;
expression
- From:
The Chinese Journal of Clinical Pharmacology
2015;(23):2293-2296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the clinical efficacy of alteplase com-bined with butylphthalide sodium chloride injection on patients with acute cerebral infarction and its effect on the expression of serum stress factors. Methods A total of 142 patients with acute cerebral infarction were ran-domly divided into treatment group and control group, with 71 cases each.Patients in two groups were all treated with butylphthalide sodium chloride injection100 mL each time, twice a day, with over 6 h interval, injection time was 50-70 min.Alteplase was added in treatment group on the basis of control group, 5 mg alteplase was dissolved in 10 mL 0.9%NaCl for intravenous injection within 10 seconds.The remaining 45 mg was dissolved 0.9% NaCl in 100 mL for intravenous injection within 60 min, the injections were proceeded once a day.The course was 2 weeks of the two groups.The clinical efficacy and the changes of neu-rological function and expression of stress factor of the 2 groups were compared.Results The total effective rate in treatment group was 95.8%, and 83.1% in control group ( P<0.05 ) .Cerebral infarction volume and US National institutes of health stroke scale ( NHISS ) significantly reduced at 1 and 2 weeks after treatment in both groups, Barthel index ( BI) significantly increased ( P<0.05).The improvement in the treatment group was more obvious (P<0.05).Interleukin -6 (IL-6), IL-8, IL-10, C-reaction protein significantly decreased (P<0.05) after 1 and 2 weeks treatment in both groups, treat-ment group obviously decreased( P<0.05).Conclusion Alteplase combined with butylphthalide sodium chloride in-jection could reduce the expression of serum stress factor in patients with acute cerebral infarction, and could control the volume of cerebral infarction and improve the neural function.
