Effect of manidipine hydrochloride on kidney function in patients with hypertension
10.13699/j.cnki.1001-6821.2015.23.002
- VernacularTitle:盐酸马尼地平对高血压患者肾功能的影响
- Author:
Ying-Na SHEN
1
;
Xiao-Na CHI
;
Li-Chun FENG
;
Bao-Luo WAN
;
An-Na XU
;
Xiao-Tian LI
Author Information
1. 郑州大学药学院
- Keywords:
manidipine hydrochloride;
amlodipine besylate;
hypertension;
kidney function;
heart rate
- From:
The Chinese Journal of Clinical Pharmacology
2015;(23):2284-2286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of manidipine hydrochloride on kidney function in patients with hypertension. Methods One hundred and thirty -three hypertensive patients with renal dysfunction were randomly divided into treatment group ( n=73 ) and control group (n=60).Treatment group was treated with manidipine 10 mg? d-1,qd, and control group was treatment with amlodipine 5 mg? d-1 for 2 weeks. If the diastolic pressure≥90 mmHg after treatment, the manidipine in-creased to 20 mg? d-1 and amlodipine increased to 10 mg? d-1 .The trial lasts 13 weeks totally.The blood puressure, heart rate, blood creatinine and 24 h urinary protein of the two groups were observed. Results The blood pressure was significantly decreased in both groups (P<0.05).Heart rate was significantly reduced in treatment group ( P<0.05) , the average blood creatinine levels dropped to normal range, 24 h urinary protein didn′t decrease to normal, but significantly declined( P<0.05) , and the creatinine clearance rate had no significant difference.The creatinine and creatinine clearance rate were significantly difference compared with those before treatment in control group ( P<0.05) , the average of 24 h urinary protein excretion significantly increased compared with before treatment. Conclusion Manidipine hydrochloride presents a useful antihypertensive and renoprotective effect on mild -to -moderate essential hypertension with kidney dysfunction patients, with no heart inhibition.
