Resistance spectrum of linezolid resistance enterococcus strains

VernacularTitle:利奈唑胺耐药的粪肠球菌临床分离株的耐药性分析
Author: Dan YAO ¹ ; Fang-You YU ; Xiao-Ying HUANG ; Xiao-Mei XU ; Liang-Xing WANG
Author Information

1. 温州医科大学附属第一医院
Keywords: enterococcus faecalis; linezolid; drug resistance; antibiotic
From: The Chinese Journal of Clinical Pharmacology 2015;31(22):2260-2262
CountryChina
Language:Chinese
Abstract: Objective To explore the condition of various types of anti-biotic resistance of enterococcus isolated in clinical.Methods Agar dilu-tion method and K-B paper diffusion method had been used to test the drug susceptibility of minimum inhibitory concentration ( MIC ) of entero-coccus isolated in clinical and to measure its minimum antibacterial depth.Results A total of 666 strains of enterococcus faecalis were isola-ted from a variety of clinical specimens, and 28 strains were linezolid re-sistance.Among these 28 linezolid resistance strains, the drug resist-ances to quinupristin, tetracyclinet, erythromycin and ciprofloxacin were 100%, 85.7%, 78.6%and 50.0%, respectively.All strains were sen-sitive to amoxicillin, 1 strains were resistant to vancomycin, 17 strains (60.7%) were intermediary resistance to vancomycin, high-level re-sistance to gentamicin was 3.6%.Conclusion Enterococcus faecalis had appeared resistance to linezolid, but the combination of aminoglyco-side and penicillins still has antibacterial activity in vitro to linezolid re-sistant enterococcus faecalis.