Clinical study of furosemide combined with brain natriuretic peptide for treatment of contrast-induced nephropathy
10.13699/j.cnki.1001-6821.2015.22.009
- VernacularTitle:呋塞米联合脑钠肽在造影剂肾病的临床研究
- Author:
Chang-Su LAI
1
;
Pei-Hua ZHOU
Author Information
1. 重庆市中医院放射科
- Keywords:
cefuroxime sammy;
brain natriuretic peptide;
contrast nephropathy
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(22):2205-2207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of small doses of furosemide combined with brain natriuretic peptide for treatment of contrast -induced nephropathy.Methods A total of 180 patients of coronary an-giography or ( and ) percutaneous coronary intervention were recruited and divided into trial group ( n =90 ) and the control group ( n =90 ) . Patients in control group were given postoperative intravenous 20 mg of furosemide, patients in trial group were given the injection of furosemide combined with brain natriuretic peptide. Renal function indexes ( concentration of serum creatinine, serum creatinine clearance and glomerular filtration rate) after operation 48 h were observed, and the in-cidence of contrast-induced nephropathy was compared between the two groups.Results After surgery, serum creatinine concentration of control group was (82.01 ±15.12) μmol·L-1 , which significantly higher than that of the trial group of (73.92 ±16.79) μmol·L-1;serum creatinine clearance of control group was ( 86.84 ±22.11 ) mL·min-1 and glomerular filtration rate was ( 83.78 ±16.69 ) mL/( 1.73 m2·min ) , all lower than those of trial group of ( 96.83 ±24.51 ) mL·min -1 and (96.95 ±21.22) mL/(1.73 m2·min).The incidence of contrast-in-duced nephropathy in trial group was 5.56%, which significantly lower than that of control group ( 24.44%, P <0.05 ) .Conclusion For the treatment of contrast-induced nephropathy, small doses of furosemide combined with brain natriuretic peptide can effectively improve the patient' s kidney function and prevent the happening of the contrast-induced nephropathy.
