Clinical efficacy and safety of milrinone combined with digoxin in the treatment of chronic pulmonary heart disease
10.13699/j.cnki.1001-6821.2015.22.004
- VernacularTitle:米力农联合地高辛治疗慢性肺源性心脏病的临床疗效及安全性评价
- Author:
Hong-Jun GU
1
;
Zhi-Xiong HU
;
Cai-Yan MA
Author Information
1. 上海市金山区众仁医院 内科
- Keywords:
milrinone;
digoxin;
chronic obstructive pulmonary disease;
pulmonary heart disease;
heart failure
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(22):2190-2192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of milrinone combined with low-dose digoxin for treatment of chronic pul-monary heart disease.Methods A total of 60 patients suffering from chronic cor pulmonale disease ( COPD ) with heart failure were rando-mized into two groups.The control group( n=30) was treated with low-dose digoxin to control heart failure.The treatment group ( n=30 ) was treated with milrinone plus low -dose digoxin to control heart failure. Other treatments were similar.Results In improvement of cardiac func-tion, the total efficiencies of control group and treatment group were 73.33%and 93.33%, respectively, there was a marked difference be-tween the two groups (P<0.05).After treatment, the alveolar oxygen partial pressure(PaO2)of two groups increased significantly (P<0.05), while the heart rate, alveolar partial pressure of carbon dioxide ( PaCO2 ) and pulmonary artery pressure decreased significantly(P<0.05)had sta-tistical significance between two groups ( P<0.01) , the above indicators of treatment group were better than those of control group. Conclusion The regimen of milrinone plus low-dose digoxin is effec-tive in controlling heart failure of patients with chronic cor pulmonale. Hence, it is worthy of being recommended in clinical practice.
