Study of relationship between the state of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels of healthy adults
10.13699/j.cnki.1001-6821.2015.21.006
- VernacularTitle:健康成年人糖代谢调节状态与血清25羟维生素 D3水平关系研究
- Author:
Ming-Xia LI
1
;
Li SHI
;
Yi-Feng ZHAO
;
Wei-Fang HAO
;
Li-Juan ZUO
;
Ming-Hui ZHANG
;
Wei-Dong REN
;
Jun GU
Author Information
1. 河北北方学院 附属第一医院 内分泌科
- Keywords:
25-hydroxyl vitamin D3;
pancreatic islet B cell function;
insulin resistance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(21):2105-2107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the state of sugar metabolic regulation and serum 25 -hydroxyl Vitamin D3[25(OH)D] levels of healthy adult. Methods A total of 102 healthy adults who were received health examination in our hospital were enroll for the study.Their state of sugar metabolic regulation were evalua-ted through the homeostasis model assessment B cell function index ( HOMA-B) , secretion index ( IS ) , the sensitive index ( IAI ) , and insulin resistance index ( HOMA-IR).Healthy adults cases were divid-ed into the 25( OH) D reduction group and normal group according to the serum 25 ( OH ) D level. Clinical data were compared between two groups.25 ( OH ) D, HOMA-B, IS, HOMA -IR followed abnormal distribution were analyzed by logarithmic transformation. Pearson correlation analysis and multiple linear regression analysis were performed to investigate the relationship between the index of sugar metabolic regulation and serum 25-hydroxyl Vitamin D3 levels. Results The serum 25(OH)D level of 64 cases (62.7%) decreased.Lg(HOMA-B), Lg(IS), IAI of the 25(OH)D reduction group were significantly higher than those of normal group ( P<0.05 ) , and Lg ( HOMA -IR ) was significantly lower than that of normal group(P<0.05).Lg[25(OH)D] was positively correlated with Lg(HOMA-B), Lg(IS),IAI(P<0.05),andnegativelycorrelatedwithLg(HOMA-IR)(P<0.05).Conclusion 25(OH)D could improve the function of pancreatic islet B cell and sensitivity of insulin, thus the adults with decreased serum 25 ( OH) D level are advised to receive appropriate VD supplement.
