Clinical research on gabapentin and stellate ganglion block in the treatment of chronic tension-type headache
10.13699/j.cnki.1001-6821.2015.21.004
- VernacularTitle:加巴喷丁联合星状神经节阻滞治疗慢性紧张性头痛的临床研究
- Author:
Jian-Jun CHEN
1
;
Yue-Jin HUANG
;
Zhi-Ping WU
;
Hui-Fen HUANG
Author Information
1. 丽水市中心医院 神经内科
- Keywords:
chronic tension-type hea dache;
gabapentin;
stellate ganglion block;
pain;
anxiety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(21):2099-2101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of gabapentin combined with stellate ganglion block in the treatment of chro-nic tension-type headache.Methods One hundred and sixty-six pa-tients with chronic tension -type headache were randomly divided into experiment group ( n=83 ) and control group ( n=83 ) .All of the sub-jects received oral gabapentin at initial dose of 100-200 mg? d-1 , the dose could be adjusted gradually according to the therapeutic effect.Pa-tients in experiment group combined with stellate ganglion block, 2 times a week; patients in control group took eperisone 50 mg, orally, three times a day.The pain ( assessed before the treatment and every Friday during treatment period ) , depression and anxiety ( assessed before the treatment and every other Friday during treatment period) , quality of life assessment( assessed before and after the treatment ) of the two groups were observed.Results The pain scores were significantly lower after treatment ( P<0.01 ) , but there was no significant difference between the two groups ( P>0.05 ) .The increase of gabapentin in experiment group was obviously less than that in control group ( P<0.01).The de-pression and anxiety after treatment significantly reduced than that of before treatment (P<0.01);14 d after treatment, there was no significant difference between two groups (P>0.05);28 d after treatment, depression scores of patients in experiment group were significantly lower than that in control group (P<0.01), but there were no significant differences in anxiety between the two groups (P>0.05).Conclusion Patients with chronic tension-type headache took gabapentin combined with stellate ganglion block had better curative effect and compliance with less side effect.
