Clinical effcet of dexmedetomidine in mechanically ventilated patients in intensive care unit
10.13699/j.cnki.1001-6821.2015.21.003
- VernacularTitle:右美托咪定对重症监护病房机械通气患者的临床疗效
- Author:
Yong-Gang TIAN
1
;
Lu-Jun QIAO
;
Xiu-Mei SONG
Author Information
1. 东营胜利油田中心医院 重症医学科
- Keywords:
dexmedetomidine;
bispectral index;
sedation
- From:
The Chinese Journal of Clinical Pharmacology
2015;(21):2096-2098
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the sedation effect of dexmedetomi-dine and bispectral index for the treatment of intensive care unit( ICU) patients with mechanical ventilation.Methods A total of 58 postopera-tion ICU patients needing mechanical ventilation were randomized into treatment group and control group. Treatment group was intravenous injected dexmedetomidine 0.5 μg? kg-1 , and 0.2 μg? kg -1? h-1 in-travenous infusion.Control group was intravenous infusion loading dose of midazolam 0.06 mg? kg -1 , intravenous infusion 0.4 mg? kg-1? h-1 to maintain sedation.The arterial pressure ( MAP) , respiratory rate ( RR) , pulmonary cardiac blood oxygen saturation ( SpO2 ) , heart rate ( HR ) , Ramsay score, bispectral index ( BIS) , adverse reactions and complica-tions at different times were monitored.Results MAP, RR, HR and SpO2 at each time were no difference after sedation ( P>0.05).RR and HR decreased obviously compared with before sedation ( P<0.05). Compared with before sedation, BIS value significantly decreased, Ram-say score was significantly higher ( P<0.05 ) .After sedation, the BIS value and Ramsay score had no difference between the two groups (P>0.05).Delirium,beckoning too moderate and hypotension incidence in treatment group were lower those of con-trol group ( P<0.05 ) , duration from ICU arrival to off time and diastasis were significantly shorter than that of control group( P <0.05 ) .Conclusion Dexmedetomidine has good sedation effect for patients with mechanical ventilation with reduced adverse reactions and complications.
