Review of microRNA related to the metastasis of colorectal cancer
10.13699/j.cnki.1001-6821.2015.20.031
- VernacularTitle:与结直肠癌转移相关的微小 RNA研究现状
- Author:
Yong-Hong PENG
1
;
Guo-Hao CAI
;
Xue-Qiao YU
;
Wei-Ping ZHOU
Author Information
1. 海南省人民医院消化外科
- Keywords:
colorectal cancer;
metastasis;
microRNA;
relationship
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2080-2083
- CountryChina
- Language:Chinese
-
Abstract:
Metastasis is one of the leading cause of death in patients with colorectal cancer.MicroRNA ( miRNA) can regulate epithelial-mesen-chymal transition, oncogenes, tumor suppressor genes and tumor metasta-sis related genes, and combine target gene mRNA by binding to comple-mentary sites to regulate the expression of target genes in post-transcrip-tional, thus regulate the tumor occurrence and development.In recent years, more and more studies show that miRNAs play important roles in the metastasis of colorectal cancer, which is expected to become a new target for the treatment of colorectal cancer.
