Research progress on β-Sheet breaker peptides in treatment of Alzheimer′s disease
10.13699/j.cnki.1001-6821.2015.20.030
- VernacularTitle:β－片层阻断肽用以治疗阿尔茨海默病的研究进展
- Author:
Jian-Jun GUO
1
;
Teng-Fei QUAN
;
Yong-Yue ZHAO
;
Wei-Feng TAN
;
Lin-Yu ZHU
;
Jing ZHU
;
Meng-Sha LI
;
Hai-Zhi BU
Author Information
1. 苏州圣苏新药开发有限公司
- Keywords:
Alzheimer ’ s disease;
dementia;
amyloid β-peptide;
β-Sheet breaker peptide
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2076-2079
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease ( AD ) is a common neurodegenerative disorder that causes progressive memory and cognitive impairment and ul-timately leads to death of patients.Aggregation of amyloid β-peptide ( Aβ) is a central event in AD pathogenesis, which is based onβ-sheet formation of Aβpeptides.β-Sheet breaker peptides are oligopeptides that can prevent and/or reverse β-sheet formation and thus represent a promising class of candidates for treatment of AD. This review is to summarize the progress of β-Sheet breaker peptides made in the past few decades.
