Validation of relationship between vancomycin trough concentration and nephrotoxicity:A Meta-analysis based on bivariate model
10.13699/j.cnki.1001-6821.2015.20.024
- VernacularTitle:万古霉素血药谷浓度与肾毒性相关性的验证：基于双变量模型的 Meta分析
- Author:
Peng MEN
1
;
Hui-Bo LI
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
vancomycin;
trough concentration;
nephrotoxicity;
bivariate model;
Meta-analysis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2058-2061
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between vancomycin trough concentrations and incidence of nephrotoxicity . Methods Pubmed, EMbase, Cochrane Library, China National Knowledge Infra-structure ( CNKI ) , WanFang Data and Chinese Bio Medical Literature Database ( CBM) were systematically searched from inception to February 2014.Specificity, sensitivity and predictive odds ratios with 95% confi-dence intervals were calculated.Results Seventeen observational stu-dies and 2802 patients were included in the Meta-analysis.While cut-offs of trough concentrations were 10 , 15 or 20 mg? L-1 , pooled sensi-tivity were 0.83, 0.69 or 0.43, pooled specificity were 0.35, 0.61 or 0.83 , pooled predictive odds ratios were 2.65 , 3.60 or 3.85. Conclusion There is definitive association between vancomycin trough concentrations ( ascending from 10 to 20 mg? L-1 ) and incidence of nephrotoxicity.Trough concentration is an appropriate parameter of thera-peutic drug monitoring of vancomycin.
