Effect of mongolian medicine Menggenwusenrile on correlation factor in imiquimod-induced psoriasiform skin inflammation in mice
10.13699/j.cnki.1001-6821.2015.20.018
- VernacularTitle:孟根乌森乌日乐对银屑病样皮损小鼠相关因子表达的影响
- Author:
Yu QING
;
Zhi-Qiang HAN
;
Na TA
- Keywords:
Menggenwusenrile;
psoriasiform;
therapy;
imiquimod
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2040-2042
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and mechanism of mongolian medicine Menggenwusenrile in the treatment of imiquimod -induced psoriasiform skin inflammation in mice.Methods Fifty cases of BALB/c female mice were randomly divided into normal control group, model group, Menggenwusenrile low, middle and high dose groups, 10 cases in each group.Normal control group was given 0.3% sodium car-boxyl methyl cellulose(CMCNa) 2 mL/100 g, once a day intragastric administration for consecutive 21 days.Modal group was given 0.3%CMCNa 2 mL/100 g, once a day intragastric administration for consecu-tive 21 days.Menggenwusenrile low, middle and high dose groups were given 0.33, 0.66, 1.32 g? kg-1 , once a day intragastric administration for consecutive 21 days.The expression of proliferating cell nuclear anti-gen ( PCNA) , transforming growth factor-α( TGF-α) , tumor necrosis factor-α( TNF-α) , platelet endothelial cell adhesion molecule-1/CD31 (CD31), vascular endothelial growth factor (VEGF)and Toll -like receptors-2 ( TLR-2 ) were detected by immunohistochemical stai-ning.Results Six kinds of immunohistochemical analysis showed the each drug dose group was higher than the model group, high dose is bet-ter than middle dose group, the middle dose group is better than low dose.Conclusion Menggenwusenrile have a better therapeutic effect in imiquimod-induced psoriasiform skin inflam-mation in mice.
