Study on the resistance of Staphylococcus epidermidis to mupirocin
10.13699/j.cnki.1001-6821.2015.20.012
- VernacularTitle:表皮葡萄球菌对莫匹罗星的耐药性研究
- Author:
Chun-Chan LIN
1
;
Shu-Ying CHEN
;
Yu DING
;
Dan LI
;
Xue-Qing ZHANG
;
Liang-Xing WANG
;
Fang-You YU
Author Information
1. 温州医科大学 附属第一医院 检验科
- Keywords:
Staphylococcus epidermidis;
mupirocin;
resistance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2021-2023
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the resistance of Staphylococcus epidermidis isolates to mupirocin and its resistant characteristics to anti-bacterial agents used in clinical.Methods A total of 489 Staphyloco-ccus epidermidis isoliates were isolated from the various specimens of pa-tients in our Hospital.The identification and antimicrobial susceptibility testing of Staphylococcus epidermidis isolates were determined by Vitek-2 Compact full automated Microbiology Analyzer.The susceptibility of 489 Staphylococcus epidermidis isolates to mupirocin was determined by disc-diffusion method.Results Among 489 Staphylococcus epidermidis clini-cal isolates, 39 methicillin -resistant Staphylococcus epidermidis ( MRSE) were resistant to mupirocin.The prevalence of mupirocin resis-tance among Staphylococcus epidermidis clinical isolates was 7.8%(39/498).All mupirocin-resistant isolates were susceptible to quinu-pristin/dalfopristin, linezolid, vancomycin and nitrofurantoin. While more than 60%of mupirocin-resistant isolates were resistant to penici-llin, clindamycin, erythromycin and trimethoprim/sulfamethoxazole.The resistance rates of mupirocin -resistant isolates to gentamicin and rifapin were more than 35%. Conclusion Mupirocin is an effective agent against Staphylococcus epidermidis isolates in vitro.However, the mupiro-cin-resistant Staphylococcus epidermidis has appeared in clinical isolates which is of concern.
