Clinical efficacy of Xiaojie′an capsule in breast hyperplasia patients and its effect on serum hormone levels and immune function
10.13699/j.cnki.1001-6821.2015.20.007
- VernacularTitle:消结安对乳腺增生的临床疗效及对激素水平和免疫功能的影响
- Author:
Gang BAO
1
;
Jian-Jun HUANG
;
Tian ZHOU
Author Information
1. 贵阳医学院附属医院 乳腺外科
- Keywords:
Xiaojie′an capsule;
hyperplasia;
serum hormone;
immune function
- From:
The Chinese Journal of Clinical Pharmacology
2015;(20):2005-2007
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Xiaojie′an capsule in breast hyperplasia patients and its effect on serum hormone levels and immune function.Methods A total of 116 cases of breast hy-perplasia patients were randomly divided into treatment group ( n=59 ) and control group ( n =57 ) .The control group received conventional treatment and the treatment group was used Xiaojie′an capsules 0.76 g, tid, on the bases of control group.The course was 8 weeks.Clinical effi-cacy, serum hormone levels, immune function parameters, pain score, tumor size and tumor hardness score before and after treatment were observed.Results The total efficiency in treatment group ( 94.92%) was significantly higher than that of control group (82.46%, P<0.05). The luteinizing hormone ( LH ) , progesterone ( P ) in treatment group were significantly higher than those of control group ( P<0.05) , and es-tradiol ( E2 ) and prolactin ( PRL ) levels were significantly lower than those of control group ( P <0.05 ) .The CD3+, CD4+, CD4+/CD8+ were significantly higher than before treatment ( P<0.05) , and CD8+was sig-nificantly lower than before treatment in two groups ( P <0.05 ) .The CD3+,CD4+/CD8+in treatment group were significantly higher than those of control group( P<0.05 ) , but CD8+was significantly lower ( P<0.05 ) .The pain scores, tumor size and tumor hardness score were significantly reduced than those of before treatment ( P<0.05 ) , and treatment group was signifi-cantly lower than control group (P<0.05).Conclusion Xiaojie′an capsule had significant effect on mammary gland hyperplasia, and can regulate the endocrine and immune function.
