Study on the resistance of Staphylococcus aureus clinical isolates to fusidic acid
10.13699/j.cnki.1001-6821.2015.19.026
- VernacularTitle:金黄色葡萄球菌临床分离株对夫西地酸的耐药性分析
- Author:
Shu-Ying CHEN
1
;
Chun-Chan LIN
;
Chao-Hui LU
;
Yun-Ling LIU
;
Xue-Qing ZHANG
;
Liang-Xing WANG
;
Fang-You YU
Author Information
1. 温州医科大学 附属第一医院 检验科
- Keywords:
Staphylococcus aureus;
fusidic acid;
resistance;
minimal inhibitory concentration
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1971-1973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of fusidic acid ( FA) resistance among Staphylococcus aureus clinical isolates.Methods Five hundred fifty -five Staphylococcus aureus isolates were isolated from the various specimens of patients at the first affiliated hospital of Wenzhou medical university from January , 2009 to September , 2013. The susceptibility of Staphylococcus aureus isolates to FA and clinically often used antimicrobials was determined by disc diffusion method .The minimal inhibitory concentrations ( MICs ) of FA and vancomycin for FA-resistant isolates was determined by agar dilution method . Results Among 555 Staphylococcus aureus isolates, 293 were methici-llin-resistant Staphylococcus aureus ( MRSA) and 262 were methicillin-susceptible Staphylococcus aureus ( MSSA ) .Seventy -seven of 555 ( 13.87%) isolates including 60 MRSA and 17 MSSA isolates were resistant to FA.The rates of FA resistance among MRSA and MSSA iso-lates were 22.90% ( 60/262 ) and 5.80% ( 17/293 ) . The rates of FA resistance among Staphylococcus aureus isolates from 2009 to 2013 were 7.81% ( 5/64 ) , 9.80% ( 5/51 ) , 22.92%(11/48), 5.21%(11/211) and 24.86%(45/181), respectively.The MICs of FA for 77 FA -resistant isolates ranged from 2 to >64 μg? mL-1 , among which 44 with fusidic acid MIC of >64 μg? mL-1 .All FA-resis-tant isolates were susceptible to quinupristin -dalfopristin , vancomycin , linezolid and nitrofurantoin .While more than 50% of theses isolates were resistant to penicillin , tetracycline , clindamycin , erythromycin and ciprofloxacin . Conclusion FA has fine antimicrobial activity in vitro against Staphylococcus aureus isolates, but the FA resistance among these isolates was increasing , especially increased high -level FA resistance.
