Clinical effect and safety of sertraline combined with psychotherapy for adolescents with obsessive-compulsive disorder
10.13699/j.cnki.1001-6821.2015.19.015
- VernacularTitle:舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性评价
- Author:
Hai-Liang FANG
1
;
Xiao-Xiong HAO
;
Tong CHEN
;
Kang DAI
;
Zhao-Hui HUANG
Author Information
1. 第三军医大学 卫生勤务学教研室
- Keywords:
seculin;
psychotherapy;
adolescent;
disorder
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1937-1939
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical effect and safety of sertra-line plus psychotherapy on adolescent obsessive -compulsive disorder pa-tients.Methods One hundred and ten cases of adolescent patients with obsessive -compulsive disorder were randomly divided into treatment group and control group , each group 55 cases.Sertraline was given to the two groups , treatment group given psychological treatment on the basis . To compare the clinical effect of the two groups .Results Total efficien-cy in treatment group was 85.5%, significantly higher than that in con-trol group , which was 63.6%( P<0.05 ) .The scores of Yale -Brown obsessive -compulsive scale and Hamilton depression scale after treat-ment in the two groups were significantly lower than before treatment , and the treatment group was more significantly ( P<0.05 ) .During the treatment, the treatment emergent symptom scale ( TESS) scores had no significant difference of the two groups ( P >0.05 ) , but the treatment group was significantly lower than control group (P<0.05).Conclusion Seculin combined with psychological treatment can improve the clinical symptoms of adolescents with obsessive -compulsive disorder , and can reduce the incidence of adverse reactions , with good efficacy and safety .
