Clinical efficacy and safety evaluation of cornu cervi degelatinatum in the treatment of leukopenia after chemoradiotherapy of malignant tumor
10.13699/j.cnki.1001-6821.2015.19.014
- VernacularTitle:鹿角霜治疗恶性肿瘤放化疗后白细胞减少症的临床疗效及安全性评价
- Author:
Tian-Yi QUAN
1
;
Wen-Yu CHEN
;
Guo-Hong HUANG
;
Ying-Fang ZHOU
;
Chong-Lian FENG
;
Wei-Ming LI
;
Xue-Hu XU
Author Information
1. 广州医科大学 附属第三医院 肿瘤科
- Keywords:
cornu cervi degelatinatum;
malignant tumor;
leukopenia;
clinical efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1934-1936
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical efficacy of cornu cervi dege-latinatum in treating leucopenia after malignant tumor chemoradiotherapy . Methods Sixty cases with leucopenia after malignant tumor chemoradio-therapy and kidney yang deficiency in Chinese medicine were randomly divided into treatment group and control group ,30 cases in each group. Patients in control group were treated with leucogen 40 mg once, 3 times a day.Patients in treatment group were treated with cornu cervi degelati-natum 100 g once a day .Two weeks for a course , and both groups were treated for 3 courses.The leukocyte account before and after treatment and the clinical effect after treatment of two groups were compared , also the security was evaluated . Results The total effective rate was 86.67%in treatment group , much higher than 73.33%in control group ( P<0.05 ) .The leukocyte number apparently rised after treatment in both groups ( P <0.05 ) , while in treatment group , it rised to much higher than that in control group ( P<0.05 ) .The incidence of adverse drug reactions of the two groups was compared , and the difference was not statistically significant ( P >0.05 ) . Conclusion Compared to leucogen , cornu cervi degelatinatum has better clinical effect on the treatment of leucopenia after malignant tumor chemoradiotherapy with good security , which is worth recommended in clinical .
