Effect of levothyroxine on the serum concentration of folate acid and thyroid function in pregnant women with subclinical hypothyroidism
10.13699/j.cnki.1001-6821.2015.19.007
- VernacularTitle:左旋甲状腺素治疗对亚临床甲状腺功能减退症孕妇血清叶酸和甲状腺功能的影响
- Author:
Jing-Xiong ZHOU
1
;
Lu-Hong LI
;
Ting LI
;
Zi-Ping ZHANG
;
Xiang-Min LUO
;
Su-Zhen HUANG
;
Xi-Sheng LI
Author Information
1. 福建医科大学 附属第二医院 内分泌科
- Keywords:
levothyroxine;
hypothyroidism;
pregnancy;
folic acid
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1913-1915,1930
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of levothyroxine on the serum concentration of folate acids and thyroid function in pregnant women with subclinical hypothyroidism .Methods A total of 95 subjects including 65 pregnant women during the second and third trimesters and 30 controls were involved in this study .The participants were divided into three groups based on the thyroid function:30 pregnant women with subclinical hypothyroidism ( A group ) , 35 pregnant women with normal thyroid function ( B group ) and 30 fertile women with normal thyroid function ( C group ) .The patients in A group were treatment with levothy-roxine.The levels of folate, thyroid stimulating hormone , free thyroxine ( FT4 ) , free triiodothyronine ( FT3 ) , fasting plasma glucose , total choles-terol, triglyceride,high density lipoprotein -cholesterol(HDL-C), low density lipoprotein-cholesterol(LDL-C) were detected before and after treatment.Results Serum folate concentration in the A group were sig-nificantly lower than that in the B group and C group (P<0.01).Levels of total cholesterol and LDL -C in the A group were significantly higher than those in the B group and C group ( P<0.01 ) .The level of thyroid-stimulating hormone has a mild inverse correlation with the level of folate concentra-tion( r=-0.20 , P>0.05 ) , but has a positive correlation with total cholesterol and LDL -C levels ( r=0.21 and 0.29 , P<0.05 ,respectively ) in pregnant women .In A group patients , folate concentration significantly increased , but the level of thyroid -stimulating hormone level significantly decreased after treatment ( both P<0.05 ) .The changes of free triiodothyronine or free thyroid hormone level was not significantly ( both P>0.05 ) .Conclusion Lower folate concentration , higher total cholesterol and LDL -C levels may be considered as risk factors of bad pregnancy outcomes in pregnant women with subclinical hypothyroidism .Treatment with levothyroxine can significantly increase serum folate and reduce thyroid-stimulating hormone , which might have a positive meaning for improving pregnancy outcome .
