Clinical research of metformin combined with saxagliptin or glimepiride in patients with type 2 diabetes mellitus inadequately controlled with metformin
10.13699/j.cnki.1001-6821.2015.19.006
- VernacularTitle:单用二甲双胍控制不佳的2型糖尿病患者联用沙格列汀或格列美脲的临床研究
- Author:
Guang-Ming CHEN
1
;
Yan-Fei HU
;
Xue-Yong LOU
Author Information
1. 金华市中心医院 内分泌科
- Keywords:
type 2 diabetes mellitus;
metformin;
saxagliptin;
fasting plasma glucose;
hemoglobin A1c
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1910-1912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and safety of metformin com-bined with saxagliptin or glimepiride in patients with type 2 diabetes me-llitus inadequately controlled with metformin alone .Methods Sixty pa-tients with type 2 diabetes mellitus inadequately controled by metformin alone were randomly divided into trial group and control group , 30 pa-tients in each group .The two groups maintain the original dose of met-formin and usage unchanged , patients in trial group were given oral saxa-gliptin 5 mg, once a day , and the patients in control group were treated with glimepiride 1-4 mg once daily before breakfast .The treatment las-ted 12 weeks.The data of fasting plasma glucose ( FPG) , 2 h postpran-dial plasma glucose(2 h PG), hemoglobin A1c(HbA1c), lipids weight, fasting insulin ( FINS) , homeostasis model assessment of β-cell function ( HOMA -β) were recorded and compared between the two groups . Results The serum levels of FPG , 2 h PG and HbA1 c were significantly decreased in two groups after treatment ( P<0.05 ) , but had no signifi-cant differences between the two groups .Compared with control group , the levels of FINS and HOMA-βstatistically increased after treatment in the trial group ( P <0.05 ) .There was no serious adverse reaction in both groups during the treatment , the incidence of mild hypoglycemia was significantly less in trial group ( P<0.05 ) . Conclusion The blood glucose control of saxagliptin is comparable to glimepiride , but saxagliptin showed a better effect on the improvement of β-cell function and decrease of the risk of hypoglycaemia .
