Feasibility study of the changes of serum lectin in guiding early diagnosis of liver cancer
10.13699/j.cnki.1001-6821.2015.19.005
- VernacularTitle:血清凝集素变化指导肝癌早期诊断的可行性研究
- Author:
Rong-Jiang LI
1
;
Jian-Ying HUANG
;
Lei ZHANG
;
Xian-Cheng ZENG
Author Information
1. 深圳市宝安区西乡人民医院 普外科
- Keywords:
serum protein;
serum alpha-fetoprotein;
alpha-fetoprotein heterogeneity;
Golgi membrane protein 73;
liver cancer
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1907-1909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the feasibility and clinical value of serum protein markers for early diagnosis of liver cancer .Methods A total of 60 patients with hepatocellular carcinoma ( A group ) , 35 patients with liver cirrhosis ( B group ) , 15 patients with other diseases ( C group ) , 15 healthy persons ( control group ) were selected for the study.Venous blood was collected to detect alpha -fetoprotein (AFP), AFP heterogeneity ( AFP-L3 ) , Golgi membrance protein 73 ( CP73 ) , the correlation of tumor size and BCLC classification was analyzed . Results The serum AFP, AFP-L3, GP73 levels in group A were sig-nificantly higher than those in other three groups (P<0.05).There was no significant correlation between tumor size and serum levels of AFP and GP73 , and there was significant correlation between tumor size and serum AFP-L3; no significant correlation between the number of tumors and serum AFP, AFP-L3, CP73.There was a positive correlation between BCLC classification and AFP , AFP -L3 , the sensitivity of AFP was 85.7%, specificity was 72.9%; the sensitivity of AFP -L3 was 58.0%, specificity was 87.6%; the sensitivity of GP73 was 69.7%, specificity was 76.7%.Parallel test joint detection method can improve the sensitivity and negative predictive value of detection; series of tests combined detection method can improve the specificity and positivepredictive value.Conclusion Serum AFP, AFP-L3, CP73 joint detection and using positive complementary can sig-nificantly improve the accuracy of hepatic tumors diagnosis .
