Clinical efficacy and safety of minocycline in treatment of periodontal pulp syndrome
10.13699/j.cnki.1001-6821.2015.19.001
- VernacularTitle:盐酸米诺环素治疗牙周牙髓综合征的临床疗效及安全性评价
- Author:
Ping XIONG
1
;
Yun-Tao TANG
;
Hong-Gang CHEN
;
Si-Jie CHEN
;
Mei HAN
;
Li-Na WANG
;
Yong SUN
Author Information
1. 德阳市第二人民医院 口腔科
- Keywords:
minocycline;
periodontal pulp syndrome;
root canal administrated;
clinical efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;31(19):1895-1897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of mi-nocycline via root canal combined with modern root canal therapy in the treatment of periodontal pulp syndrome .Methods One hundred patients with periodontal pulp syndrome were randomly divided into treatment group ( n=50 ) and control group ( n=50 ) .Patients in control group were treated with minocycline via periodontal pocket combined with tradi-tional root canal therapy , once a week , 6 weeks.Patients in treatment group were treated with minocycline via root canal combined with modern root canal therapy , 5-7 d visit once , root canal was filled after one to several dressing to achieve root canal standard .The plaque index , tooth mobility, probing pocket depth , bleeding on probing index and gingival index were observed before and after surgery .The clinical efficacy was evaluated at the right moment , 3 months and 6 months after surgery , and the adverse drug reactions were counted .Results The plaque indexes , periodontal pocket diagnose depth , bleeding index and gingival index of patients in both groups were significantly descent after treatment( P<0.05 ) , and in treatment group , they were significantly lower than those in control group ( P<0.05 ) .The total curative effective rates in treatment group and control group were 94.00%and 82.00%( P<0.05) instantly after opera-tion, 92.00%and 80.00%(P<0.05) at three months after operation , 92.00%and 76.00%(P<0.05) at six months after operation.The incidence of adverse drug reactions of the two groups was compared and the difference was not statistical-ly significant (P>0.05).Conclusion Minocycline via root canal combined with modern root canal therapy can improve clinical effect of periodontal pulp syndrome , and suit to widely using in clinic .
