Pharmacology and clinical evaluation of suvorexant
10.13699/j.cnki.1001-6821.2015.18.026
- VernacularTitle:苏沃雷生的药理学与临床评价
- Author:
Lai-Hai WANG
1
;
Ling-Jun WANG
;
Rui-Ling ZHANG
Author Information
1. 新乡医学院第二附属医院
- Keywords:
suvorexant;
hypnotic;
orexin;
pharmacology;
clinical evalua-tion;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1883-1885
- CountryChina
- Language:Chinese
-
Abstract:
Suvorexant is a new hypnotic , it is the first orexin receptor an-tagonist approved for the treatment of insomnia , characterized by difficul-ties with sleep onset and/or sleep maintenance.Its mechanism is for dual orexin OX1R and OX2R receptor inhibitor.Suvorexant should be taked 30 min before bedtime every night 10 mg once, maximum dose of 20 mg. Effective and better tolerated treatment for insomnia .Somnolence , head-ache , and dry mouth are the most common side effects .Suvorexant ap-pears efficacious and relatively tolerable .The pharmacology ,pharmacoki-netics,clinical evaluation and safety of suvorexant were reviewed in this paper .
