Antitumor mechanism and safety of 2-(3-carboxy-1-oxopropyl) amino 2-deoxy-D-glucose on the esophageal squamous cancer in nude mice
10.13699/j.cnki.1001-6821.2015.18.018
- VernacularTitle:2-（3-羟基-1-丙酰氨基）2-脱氧-D-葡萄糖对食管癌裸鼠抗肿瘤机制及安全性
- Author:
Jing ZHANG
1
;
Jing WU
;
Fang-Xun LIU
;
Ai-Qin WANG
Author Information
1. 首都医科大学 附属北京世纪坛医院
- Keywords:
2-( 3-carboxy -1-oxoprogy1 ) amino 2-deoxy -D-glucose;
esophageal squamous cancer nude mice;
antitumor;
prolifera-tion;
apoptosis;
angiogenesis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1855-1858
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antitumor effect of 2 -(3-carboxy -1 -oxopropyl ) amino 2 -deoxy -D -glucose ( COPADG) on the esophageal cancer in nude mice .Methods Nude mice model with human esophageal carcinoma Eca -109 cell line was established.Nude mice were randomly divided into normal group , model group ( COPADG 200 mg · kg -1 ) , control group [ 5 -fluorouracil (5-FU), 25 mg · kg -1 ] and experimental group ( COPADG 200 mg· kg-1 +5 -FU 25 mg · kg -1 ) . Inhibitory rate of tumor was calculated.The tumor apoptosis were detected by flow cytometry .The bone marrow suppression and liver injury of nude was evaluated by blood test.Results The tumor inhibiting rates in model group , control group and experimental group were 54.16%, 38.78% and 73.91%, respectively.Compared with the normal group and control group , the apoptosis cell rate was higher in model group and experimental group (P<0.01).COPADG treatment could reduce the bone marrow suppression and liver injury in nude.Conclusion COPADG could inhibit the prolifera-tion and angiogenesis of esophageal cancer and induce apoptosis in nude .
