Bactericidal activity of linezolid and clindamycin against methicillin -resistant Staphylococcus aureus in vitro
10.13699/j.cnki.1001-6821.2015.18.014
- VernacularTitle:利奈唑胺与克林霉素对耐甲氧西林金黄色葡萄球菌体外抗菌活性研究
- Author:
Jia-Jun ZHOU
1
;
Rui WANG
;
Zheng-Min HE
;
Xiang-Yun MENG
;
Zheng-Sheng ZHANG
;
Wen-Jun JI
;
Wen-Ting DAI
;
Rong-Juan CAO
;
Bei-Bei LIANG
Author Information
1. 合肥市第二人民医院 药学部
- Keywords:
linezolid;
clindamycin;
methicillin-resistant Staphylococcus aureus;
multiple drug resistance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1843-1845
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determinate the antibacterial activity of linezolid and clindamycin agents of clinical methicillin -resistant Staphy-lococcus aureus ( MRSA ) in vitro.Methods The minimum inhibitory concentration ( MIC ) and minimum bactericidal concentration ( MBC ) of antibacterial agents were determined by the micro broth dilution method . Results The linezolid inhibition rate was 100%when the concentration was 2 μg · mL-1 , but clindamycin concentration was 32 μg · mL-1 . The MIC range of linezolid for MRSA was 0.25 ~2.00 μg · mL-1 , MIC50 was 1 μg · mL -1 , MIC90 was 2 μg · mL-1 , MBC50 was 8 μg· mL-1 , MBC90 was 16 μg· mL -1.The MIC range of clindamycin for MRSA was 0.25 ~32.00 μg · mL-1 , MIC50 was 16 μg · mL-1 , MIC90 was 32 μg · mL-1 , MBC50 was 32 μg · mL-1 , MBC90 was >64 μg· mL-1.Conclusion Clindamycin in the treatment of MRSA infection or suspected MRSA infection must depend on drug sensi-tivity test results.Linezolid in the treatment of MRSA infection or suspec-ted MRSA infection has higher reliability .
