Effect of blood loss on plasma concentration and auditory evoked potential index of propofol target controlled infusion
10.13699/j.cnki.1001-6821.2015.18.009
- VernacularTitle:失血对丙泊酚靶控输注时血药浓度和听觉诱发电位指数的影响
- Author:
Xiao-Guang ZHANG
1
;
Gai-Sheng YANG
Author Information
1. 河北北方学院 研究生院
- Keywords:
propofol;
target controlled infusion;
blood loss;
plasma concentration;
auditory evoked potential index
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1828-1830
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of blood loss on plasma concentration and auditory evoked potential index ( AAI) of propofol tar-get controlled infusion.Methods One hundred and eight patients ( ASA gradeⅠorⅡ) who were given surgical operation were randomly divided into three groups: group A, blood loss≤300 mL; group B,300 mL 600 mL.In three groups, in-duction and maintenance of anesthesia were performed by propofol target controlled infusion , simultaneous auditory evoked potential monitoring the depth of anesthesia .Arterial blood samples were taken at anesthetize 5 (T1),30(T2),60(T3),120(T4),180(T5),240 min(T6), and at the same time, the changes of hemodynamics and auditory evoked potential index ( AAI ) were recorded for evaluating the performances of TCI sys-tems.Results In the duration of T4 -T6 , the blood loss in group C was significantly higher than group A and B ( P<0.01 ) , group B higher than group A(P<0.05);and the volume of fluid infusion of group C was sig-nificantly higher than group A and B ( P<0.01 ) , group B higher than group A(P<0.05).The MAP of group C decreased more than group A and group B (P<0.05) in the duration of T5 -T6.The plasma concentration of T3 and T4 were lower than T1 (P <0.05);T5 and T6 significant decreased than T1 ( P<0.01 ) , group C was lower than group A ( P<0.05 ) in the duration of T 4 -T6 .The MDPE was 17.74%of group C in T6 .Conclusion Blood loss can cause the actual plasma concentration of propofol below than target concentra-tion.According to AAI monitoring to regulate target propofol concentration can maintain stable vital signs .
