Clinical efficacy and safety of cyclosporine A combined with glucocorticoid in the treatment of immunoglobulin A nephropathy with large number of protein urine
10.13699/j.cnki.1001-6821.2015.18.008
- VernacularTitle:环孢素A联合糖皮质激素治疗大量蛋白尿免疫球蛋白A肾病的临床疗效及安全性
- Author:
Hui-Yu OUYANG
1
Author Information
1. 海南省中医院药学部
- Keywords:
immunoglobulin A nephropathy;
moderate dose;
cyclosporine A;
accumulative total remission rate
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1825-1827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of cyclosporine A combined with glucocorticoid in the treatment of immuno-globulin A ( IgA ) nephropathy with large number of protein urine . Methods Fifty-six patients with IgA nephropathy were randomly divid-ed into control group ( 28 cases ) and treatment group ( 28 cases ) . Methylprednisolone 0.8 mg· kg -1· d-1(maximum dose of 48 mg· d-1) was given to the control group , oral, twice a day, treated for 6 months. The treatment group was poured methylprednisolone at a starting dose of 0.5 mg· kg-1 · d -1 ( maximum dose 36 mg· d -1 ) , cyclosporine A with the initial dose of 100 mg· d-1 , less than 5 mg · kg -1 · d -1 , the con-centration of cyclosporine A was maintained at 100 -200 mg · mL-1 , and oral drug delivery , twice a day , the course of treatment was 6 months.Compared the clinical efficacy , renal function and adverse drug reactions rate between the two groups .Results After 24 weeks of treat-ment, the complete remission of treatment group (57.14%) was signifi-cantly higher than that of the control group (39.19%, P<0.05).After 2 weeks treatment , the urinary protein in treatment group (0.78+0.14 ) g was significantly lower than that in control group ( 1.08 +0.21 ) g (P<0.05).The incidence adverse drug reactions in two groups had no statistical difference ( P>0.05 ) .Conclusion Cyclosporine A combined with glucocorticoid of medium dose ( 0.5 mg· kg -1 · d-1 ) has better clinical efficacy and less adverse reactions on the treatment of IgA nephropathy , and is worth to recommend in clinical practice .
