Clinical efficacy and safety evaluation of cinepazide maleate in the treatment of renal colic
10.13699/j.cnki.1001-6821.2015.18.007
- VernacularTitle:马来酸桂哌齐特治疗肾绞痛的临床疗效及安全性评价
- Author:
Yu-Peng FENG
1
;
Xiang-Dong YE
;
Xue-Xiong LIAN
;
Li LI
;
Feng LI
;
Shi-Jia ZHAO
;
Yao-Jun LIAO
;
Wen-Zheng WU
Author Information
1. 广州医科大学 附属第四医院 泌尿外科
- Keywords:
renal colic;
cinepazide maleate;
adenosine;
oxygen free radicals;
spasmolysis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1822-1824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical therapeutic effect of cine-pazide maleate in the treatment of renal colic .Methods Seventy -six patients of renal colic were randomly divided into 2 groups.The control group(36 patients) received lornoxicam 8 mg and progesterone 40 mg by intramuscular injection qd.The treatment group ( 40 patients ) received cinepazide maleate 320 mg by intravenous drip qd additionally.The de-gree of pain relief , recurrence and incidence of adverse reactions were observed in 6 h.Results The efficiency and significant efficiency of the treatment group were 100.00%and 92.50%.In contrast , the efficiency and significant efficiency of the control group were 88.89%and 69.44%respectively and the differences were statistically significant .Within 6 hours of treatment, treatment group recurrent rate of renal colic (0), was lower than that of control group ( 13.89%) .The two groups were no obvious adverse reaction of drug associated .Conclusion Cinepazide maleate could obviously relieve renal colic , reduce the recurrence rate , and not lead to significant adverse reactions .So, cinepazide maleate is a new choice for the treatment of renal colic .
