Clinical efficacy and safety analysis of moxifloxacin versus levofloxacin in the treatment of elderly patients with community acquired pneumonia
10.13699/j.cnki.1001-6821.2015.18.001
- VernacularTitle:莫西沙星与左氧氟沙星序贯治疗老年社区获得性肺炎的临床疗效及安全性评价
- Author:
Shen-Xia REN
1
;
Zhen-Qiu FU
;
Ming-Dong WU
Author Information
1. 宁海县中医医院 药剂科
- Keywords:
community acquired pneumonia;
elderly patients;
moxifloxacin;
levofloxacin;
clinical efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(18):1803-1805
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety analy-sis of moxifloxacin versus levofloxacin in the treatment of elderly patients with community acquired pneumonia ( CAP ) . Methods Sixty -two elderly patients with CAP were randomly divided into treatment group ( n=32 ) and control group ( n=30 ) .Patients in treatment group were treated with moxifloxacin 400 mg by intravenous transfusion , qd with changes for orally administration 400 mg qd after improvement.Patients in control group were treated with levofloxacin 500 mg by intravenous transfusion , qd with changes for orally administration 100 mg tid after improvement.The total course of administration was less than 2 weeks. The clinical efficacy , total course of administration , pathogenic bacteria clearance rate and safety were evaluated between the two groups . Results The total efficacy was not significant different between the two groups ( P>0.05 ) , but the cure rate in treatment group was significant higher than that in control group ( P<0.05 ) .The total course of drug administration of treatment group was shorter than control group (P<0.05).The pathogenic bacteria clearance rate was 93.75% and 83.33%for treatment and control group respectively which indicated that treatment group was significant higher ( P<0.05 ) .And the drug related
toxicity was not statistically different between the two groups ( P>0.05 ) .Conclusion Both moxifloxacin and levoflo-xacin were effective and safe in the treatment of elderly patients with community acquired pneumonia .And moxifloxacin had higher pathogenic bacteria clearance effects .
