Effects of different dose Jisuikang on spinal cord -evoked potentials after spinal cord injury in rats
10.13699/j.cnki.1001-6821.2015.17.022
- VernacularTitle:不同浓度脊髓康对脊髓损伤大鼠诱发电位的影响
- Author:
Heng YIN
1
;
Jun-Feng YANG
;
Yong MA
;
Jing FAN
;
Ya-Feng ZHANG
;
Jie ZHANG
;
Jian-Wei WANG
Author Information
1. 南京中医药大学
- Keywords:
Jisuikang;
spinal cord injury;
sensory evoked potentials;
mo-tor evoked potentials
- From:
The Chinese Journal of Clinical Pharmacology
2015;(17):1773-1776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different concentrations Jisuikang on spinal cord -evoked potentials after spinal cord injury in rats.Methods Sixty SD rats were divided into 6 groups randomly ,sham group, model group, control group(prednisone,0.06 g· kg -1· d-1), the high -dose , mid -dose , low -dose ( Jisuikang , 50 , 25 , 12.5 g· kg -1 · d-1 ) test groups.The sensory evoked potentials ( SEP) and motor evoked potentials ( MEP) were tested at preoperative and postoper-ative 0, 3, 7, 14, 28 d.Then the changes of the incubation period and amplitude were observed.Results Test mid-dose group has precede effect than test-L group and the test -H on the changes of the SEP in-cubation period and amplitude , but no obvious difference compared with control group.The test mid-dose group has the same effect with control group on the MEP incubation period , better than test high -dose group and test low-dose group.Test mid-dose group has precede effect than other groups on the MEP amplitude.Conclusion The mid -dose Jisuikang has the best curative effect for neural functional recovery after spinal cord injury.
