Comparison the protective effect of new and old extraction of Leech in Zhilonghuoxuetongyu capsule on cerebral ischemia in rats
10.13699/j.cnki.1001-6821.2015.17.021
- VernacularTitle:水蛭新旧提取法制备蛭龙活血通瘀胶囊对脑缺血保护作用的比较研究
- Author:
Si-Jin YANG
1
;
Xue BAI
;
Qing-Rong PU
;
Qin SUN
;
Jun-Ning ZHAO
;
Wei WANG
Author Information
1. 四川医科大学 附属中医医院心脑病科
- Keywords:
Zhilonghuoxuetongyu capsule;
cerebral ischemia;
methane dicarboxylic aldehyde;
superoxide dismutase
- From:
The Chinese Journal of Clinical Pharmacology
2015;(17):1769-1772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the protection effect of new and old extraction of Leech in Zhilonghuoxuetongyu capsule on the focal cerebral ischemia in rats.Methods Ninety SD rats were randomly divided into 9 groups:control group , model group , Buchangnaoxintong group , the new ( A) and old ( B) capsule with large , medium and small dose groups.To fill the stomach in one times a day , for five consecutive days later .And compared the neurological function score , infarction range , pathological changes , and serum methane dicarboxylic aldehyde ( MDA ) , superoxide dismutase ( SOD ) content were be detected by colorimetric method.Results Compared with model group,the new and old capsule of large dose group were lower the neurological function score.The new and old capsule of large dose and old capsule of medium dose can reduce wet weight , dry weight and percentage of cerebral ischemia.The degree of swelling of the nerve cells necrosis , change of nucleus , proliferation of Glial cell in new capsule of high dose and old capsule of high , middle dose were lighter than model group.The MDA content in the new and old capsule of large dose group were lower , there are significant differences ( P <0.05 ).Conclusion The new and old extraction of Leech in Zhilonghuoxuetongyu capsule all have protective effect on focal cerebral ischemia in rats , may be related to reduce the serum MDA.
