Efficacy and safety of methylprednisolone in the treatment of traumatic brain edema
10.13699/j.cnki.1001-6821.2015.17.005
- VernacularTitle:注射用甲泼尼龙琥珀酸钠治疗外伤性脑水肿的疗效与安全性
- Author:
Bin ZHAO
1
;
Xin YAO
Author Information
1. 天津医科大学
- Keywords:
methylprednisolone;
dexamethasone;
brain edema;
prognosis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(17):1716-1717,1735
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safetys of methyl-prednisolone in the treatment of traumatic brain edema.Methods Forty nine patients with traumatic brain edema were included in this study.Of the included 49 cases, 23 patients ( experiment group ) received methyl-prednisolone 40 mg+0.9%normal saline 100 mL intravenous drip bid;26 cases( control group ) treated with dexamethasone 20 mg intravenous bid.The schedule were 7 days for the two groups.The brain edema were compared between the two groups within two weeks.The prognosis were evaluated after 6 months.Results In the next 6 months follow up , 8 pa-tients recovery well and 3 cases dead in the experiment.For control group , 6 patients recovery well and 4 patients dead.The clinical efficacy were not statistical different between the experiment and control groups ( P>0.05).The brain edema in the control group were significant severe than experiment group ( P<0.05).There was 1 case of stress ulcer in the experiment and control group.Conclusion Methylprednisolone can significant reduce the brain edema in patients with brain trauma.
