Effect of different doses of dexmedetomidine to pain, stress and immune function in elderly patients with laparoscopic surgery
10.13699/j.cnki.1001-6821.2015.17.003
- VernacularTitle:不同剂量右美托咪定对老年腹腔镜手术患者镇痛与应激及免疫功能的影响分析
- Author:
Zhi-Bing PI
1
;
Hai LIN
;
Xu-Zhong XU
Author Information
1. 温州医科大学 附属第一医院 麻醉疼痛科
- Keywords:
dexmedetomidine;
laparoscopic surgery;
analgesia;
stress;
immune function
- From:
The Chinese Journal of Clinical Pharmacology
2015;(17):1709-1712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect ofdifferent doses of dexmedeto-midine to pain , stress and immune function in elderly patients with lapa-roscopic surgery Methods One hundred twenty -six patients of laparo-scopic surgery were randomly divided into low -dose group ( 42 cases ) , middle dose group (42 cases), and high-dose group (42 cases).Be-fore anesthesia 15 min, the low dose group , middle dose group and high dose groups were intravenouslygiven 0.2 , 0.4 , 0.6 μg · kg -1 · h-1 of dexmedetomidine ,respectively.Diastolic bllod pressure ( DBP) , systolic blood pressure ( SBP) , blood sugar ( Glu) , heart rate ( HR) to the hori-zontal and CD4, CD8, CD4/CD8 levels of before and after surgery 3, 8, 24 h were compared.Results The pain scores ,DBP, SBP, Glu and HR levels of before and after surgery 24 h between three groups were not sig-nificant differences ( P>0.05 ).After surgery 3 h and 8 h, pain scores of middle high dose groups were significantly higher than that of low -dose group ( P <0.05 ) and their DBP, SBP, Glu, HR were significantly better than that of low-dose group(P<0.05).Before and after surgery, CD4 levels in three groups of patients did not change significantly.Before and 3 h after surgery, CD8, CD4/CD8 levels in the three groups were not significant difference ( P>0.05 ).After surgery 8 h and 24 h, CD8 levels of high-dose group was significantly lower than of the low -dose group , and the CD4/CD8 ratio was significantly better than low -dose group(P<0.05).Conclusion The use of 0.4, 0.6 μg· kg -1 · h-1 dexmedetomidine scheduled for laparo-scopic surgery in elderly patients have a more significant analgesic effect , can reduce stress and improve immune func-tion in patients , it is worth widely used.
