Efficacy of rosuvastatin to restenosis after percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
10.13699/j.cnki.1001-6821.2015.17.001
- VernacularTitle:瑞舒伐他汀对急性 ST 段抬高型心肌梗死患者冠状动脉支架术后再狭窄的影响
- Author:
Xiang-Wen LIANG
1
;
Ping LI
;
Jian-Ting GAN
;
Zheng-Dong WANG
;
Jian CHEN
;
Wen-Chao XIE
Author Information
1. 玉林市第一人民医院 心内科
- Keywords:
rosuvastatin;
atorvastatin;
myocardial infarction;
restenosis;
total cholesterol
- From:
The Chinese Journal of Clinical Pharmacology
2015;(17):1703-1705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of rosuvastatin and atorvastatin to restenosis after percutaneous coronary intervention in pa-tients with ST -segment elevation myocardial infarction ( STEMI ).Methods One hundred fourty -six patients with STEMI were divided into control and treatment group.Seventy -one cases in the treatment group were received the rosuvastatin 20 mg at 30 min before operation , and oral rosuvastatin 20 mg on the first day until 6 months.And 75 pa-tients in the control group were received atorvastatin 40 mg at 30 min be-fore operation , and oral atorvastatin 40 mg on the first day until 6 months.After 6 months of treatment , recurrent angina , stent restenosis rate, total cholesterol and the incidence of adverse drug reactions in two groups were compared.Results After 6 months of treatment , one case of angina pectoris and one case of restenosis in the treatment group were found.There was two patients with angina pectoris and one patient of restenosis in control group.The recurred of angina pectoris or restenosis rate was not different between the two groups ( P >0.05 ).The serum level of total cholesterol significantly decreased in both two groups ( P<0.05 ).And after 2 months of treatment , the total cholesterol in treatment group was lower than that in the control group ( P<0.05 ).During the following 6 months , 2 cases were death , 2 cases were nausea and vomit in the treatment group, and 2 cases were death and 1 case was liver function damage in the control group.No statistical difference wwas found between the two groups.Conclusion No difference for restenosis was found between the two group , but patients received rosuvastatin had lower level of total cholesterol.
