Analysis of therapeutic effect of lipid emulsion combined with hemoperfusion and hemofiltration on acute paraquat poisoning and acute lung injury in dogs
10.13699/j.cnki.1001-6821.2015.16.030
- VernacularTitle:脂肪乳联合血液灌流透析对急性百草枯中毒犬肺损伤的疗效研究
- Author:
Jia-Ze WANG
1
;
Yuan YE
;
Bin WANG
;
Xin-Ke MENG
Author Information
1. 深圳大学第一附属医院重症医学科
- Keywords:
lipid emulsion;
acute paraquat poisoning;
lung injury;
therapeutic effect
- From:
The Chinese Journal of Clinical Pharmacology
2015;(16):1659-1661,1667
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effect of lipid emul-sion combined with hemoperfusion and hemofiltration on acute paraquat poisoning and its consequence of acute lung injury.Methods A total of 24 dogs were randomly divided into A, B, C, D group.After paraquat ( PQ) 30 mg? kg -1 was given by intramuscular injection, if there was no loss during the injection process, the model of poisoning was considered to be made successfully.Then the dog models in four groups were respec-tively treated with 4 mL? kg -1 0.9%NaCl intravenous injection in group A, 4 mL? kg -1 lipid emulsion intravenous injection in group B, 4 mL? kg -1 0.9%NaCl intravenous injection combined with hemoperfu-sion and hemofiltration in group C, and 4 mL? kg -1 lipid emulsion com-bined with hemoperfusion and hemofiltration in group D.The standards of tumor necrosis factor -α( TNF -α) , interleukin -1β( IL -1β) , IL-10 , human insulin like growth factor -1 ( IGF-1 ) , transforming growth factor-1 (TGF-β1) were determined at 0, 8, 12, 24, 36 and 48 h after starting the hemoperfusion and hemofiltration.Results Every index TNF-α, IL-1β, IL-10, IGF-1, TGF-β1 of the group A was significantly higher than that in the group B, C, D at the same section (P<0.05).IngroupB,thecytokinelevelsTNF-α,IL-1β,IL-10,IGF-1,TGF-β1weresignificantlyhigher compared with group D ( P<0.05).Conclusion Lipid emulsion combined with hemoperfusion and hemofiltration can be beneficial to relieve the lung injury induced by acute paraquat poisoning.
