Clinical efficacy of hyperthermia combined with concurrent chemoradiotherapy on the treatment of advanced esophageal cancer and its effect on serum vascular endothelial growth factor
10.13699/j.cnki.1001-6821.2015.16.013
- VernacularTitle:热疗联合同步放化疗对中晚期食管癌的临床疗效及其对血清血管内皮生长因子的影响
- Author:
Jiang LV
1
;
Wen-Xiang SHOU
;
Rui-Ying LI
;
Wei-Liang ZHU
Author Information
1. 诸暨市第六人民医院 内科
- Keywords:
hyperthermia;
chemotherapy;
advanced esophageal cancer;
serum vascular endothelial growth factor;
clinical efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2015;(16):1600-1602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of docetaxel +carboplatin combined with hyperthermia on treatment of advanced esopha-geal cancer and its effect on serum vascular endothelial growth factor ( VEGF).Methods Fifty patients with advanced esophageal cancer were randomly divided into treatment group (n=25) and control group (n=25). Control group was treated with docetaxel, intravenous 75 mg? m-2 , 1 h, day 1 +carboplatin, intravenous infusion 25 mg? m-2 , day 1 -3.A period of 28 days, a total of two treatment cycles.Treatment group was treated with docetaxel, intravenous 75 mg? m -2 , 1 h, day 1 +carboplatin, intravenous infusion 25 mg? m-2 , day 1 -3, combined with the same period of hyperthermia, NRL -004 tumor hyperthermia system, heat output power 900-1200 W, twice a week, a period of 28 days, a total of two treatment cycles.Short -term clinical efficacy, serum VEGF levels and quality of life scores and the incidence of adverse drug reactions were compared between the two groups.Results After treatment, the total efficacy of 84.00%in treat-ment group was significantly higher than that in control group (68.00%, P<0.05), serum VEGF levels in treatment group were significantly decreased than that in control group ( P<0.05 ) which had a slight decrease.Quality of life score of patients in treatment group ( 54.32 ± 9.42 ) was significantly higher than that in control group (42.04 ±10.51, P <0.05 ) . The main adverse drug reactions in treatment group were nausea and vomiting (48.00%) , hair loss (56.00%) and in control group they were 52.00%and 64.00%, respectively.There were of significant differences between the two groups ( P <0.05 ) .Conclusion Docetaxel +carboplatin combined with hyperthermia on the treatment of patients with advanced esophageal cancer had more significant short-term effect, and it can effectively reduce serum VEGF levels and fewer adverse drug reactions.It is recommended to be widely adpoted in clinic.
