Clinical efficacy and safety of liraglutide combined with insulin aspart 30 injection in the treatment of refractory type 2 diabetes mellitus
10.13699/j.cnki.1001-6821.2015.16.006
- VernacularTitle:利拉鲁肽联合门冬胰岛素30治疗难治性2型糖尿病的临床疗效及安全性评价
- Author:
Pei-Jun MAO
1
;
Gui-Ling LI
;
Qian HUANG
;
Ya-Ni WANG
;
Chun-Fang LIU
;
Ying LI
Author Information
1. 解放军第323医院内分泌科
- Keywords:
liraglutide;
insulin detemir;
insulin aspart 30;
diabetes mellitus;
type 2 diabetes mellitus
- From:
The Chinese Journal of Clinical Pharmacology
2015;(16):1578-1581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of liraglutide ( Lira) combined with insulin aspart 30 injection in the treatment of type 2 diabetes poorly controlled with premixed insulin aspart 30 ( Asp 30 ) . Methods Seventy eight patients with type 2 diabetes mellitus without reaching glycemic targets were randomized into two groups.On the basis of the insulin aspart 30 and oral hypoglycemic drugs, the patients in the trial group were given liraglutide 0.6 mg? d-1 sc once per night for the first week, and 1.2 mg? d-1 for the following two to sixteen weeks, while the other patients in the control group received insulin detemir ( Det) sc once a night for 16 weeks, with the beginning dosage of 0.2 U? kg -1? d-1.Before and after the treatment, the body mass index ( BMI) , waist to hip ratio ( WHR) , fasting plasma glucose ( FPG) , fast-ing C -peptide ( FCP ) , 2 -hour postprandial plasma glucose (PPG 2 h), glycosylated hemoglobin A1c (HbA1c) and insulin resist-ance index(HOMA-IR) were tested.Also, the adverse drug reactions such as weight gain and hypoglycemia reaction were estimated. Results After the treatment, the level of FPG, PPG 2 h and HbA1c decreased obviously in both groups ( P<0.01 ) , while PPG 2 h in the trial group appeared a better improvement compared to the control group ( P<0.05) ,and BMI as well as HOMA-IR was improved significantly in the trial group after the treatment ( P<0.01).Both drugs were well tolerated with minor hypoglycemia, yet Lira appeared much safer than Det.Conclusion For treatment of refractory type 2 diabetes mellitus, liraglutide combined with insulin aspart 30 injection had certain clincal efficacy with minor adverse reaction.
