Effect of different time -window of anticoagulant therapy on secondary thrombocytosis after splenectomy
10.13699/j.cnki.1001-6821.2015.16.005
- VernacularTitle:不同时间窗抗凝治疗对脾切除后继发性血小板升高的临床研究
- Author:
Zhi-Tao YU
1
;
Peng GAO
;
Peng-Sheng LI
;
Gai LIU
Author Information
1. 广东省第二人民医院普外科
- Keywords:
splenectomy;
secondary thrombocytosis;
anticoagulant therapy;
time-window;
hypersplenism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(16):1575-1577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of different time-window of anticoagulant therapy on secondary thrombocytosis after splenectomy. Methods Total of 200 patients with splenectomy were divided into control group (n=100) and experiment group (n=100).When throm-bocyte was over 500 ×109/L, the control group was given low molecular dextran 500 mL, low molecular heparin calcium 5000 IU, aspirin 50 mg and dipyridamole 25 mg.At postoperation 24 h, the experiment group was given low molecular dextran 500 mL, low molecular heparin calcium 5000 IU, aspirin 50 mg and dipyridamole tablets 25 mg.When platelet dropped to 400 ×109/L, drug stopped to be given.The change and difference of blood platelet level were compared between the two groups. Results The blood platelet level in two groups reached peak value at 15 days after splenectomy.In experiment group, the blood platelet level increased slowly and steadily, not exceeding 500 ×109/L.In control group, the blood platelet level increased rapidly and sharply, the peak value reached ( 945.5 ±154.4 ) ×109/L.The blood platelet level of experiment group decreased steadily from the peak value, and at 21 d after splenectomy returned to normal levels.The blood platelet level of control group returned to normal levels at 25 d after splenectomy.At postoperation 3-27 d, the blood platelet level of experiment group were significantly lower than that in control group, the difference showed statis-tically significant (P<0.05).At postoperation 29 d, the blood platelet level of two groups was no statistically signifi-cant difference(P>0.05).At 3 months of splenectomy, the blood platelet level of two groups were within the normal range.Conclusion The early anticoagulant therapy ( postoperation 24 h) can effectively prevent secondary thrombocy-tosis after splenectomy, superior to conventional anticoagulant therapy.
