Clinical effect of losartan potassium on hypertension with hyperuricemia
10.13699/j.cnki.1001-6821.2015.16.002
- VernacularTitle:氯沙坦钾对原发性高血压伴高尿酸血症的临床研究
- Author:
Fang YUAN
1
;
Li-Xin WANG
;
Jin-Chai GAO
;
Pei-Long YANG
Author Information
1. 河北北方学院 研究生学院
- Keywords:
losartan;
hypertension;
candesartan;
serum uric
- From:
The Chinese Journal of Clinical Pharmacology
2015;(16):1566-1568
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of losartan potassium and candesartan in the treatment of hypertension with hyperuricemia. Methods Total of eighty patients diagnosed with hypertension with hyperuricemia were randomly divided into two groups.The patients in experiment group ( n =40 ) were given losartan potassium 50 mg? d-1 , and the control group ( n =40 ) were given candesartan 8 mg? d -1 .The treatment lasted for 8 weeks.Serum uric acid levels and blood pressure levels were measured before and after treatment respectively. Results After treatment, the reduction of systolic blood pressure (SBP) and diatolic blood pressure(DBP) were 18.95/12.70 mmHg vs 27.18/13.03 mmHg in experiment and control group (P<0.05).The overall effective rations of experiment group and control group were not significant (92.5%vs 95.0%, P>0.05).After treatment, the level of uric aciddecreased apparently in experiment group [(431.98 ±56.11) vs (495.29 ±51.04) μmol? L-1, P <0.05]. There was no significance in uric acid level before and after treatment in control group [ ( 486.79 ±60.81 ) vs ( 470.66 ±79.36 ) μmol? L-1 , P>0.05 ] .There was a positive correlation between the range of uric acid level and the decrease of systolic blood pressure level ( r=0.366, P<0.05) in experiment group.Conclusion Losartan potassium is more useful than candesartan for hypertension with hyperuricemia.
