Advances in the ventricular remodeling mediated by protein kinase C signaling pathway after myocardial infarction
10.13699/j.cnki.1001-6821.2015.15.027
- VernacularTitle:蛋白激酶 C信号通路介导心肌梗死后心室重构的研究状况
- Author:
Ling-Yan WANG
1
;
Jia-Hui YU
;
Bo GONG
;
Ya-Dong WANG
;
Guan-Wei FAN
Author Information
1. 天津中医药大学 中医药研究中心
- Keywords:
protein kinase C;
ventricular remodeling;
inflammation;
calcium circulatory disorder;
profibrotic factors release
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1555-1557
- CountryChina
- Language:Chinese
-
Abstract:
Ventricular remodeling refers to the original structural rea-rrangement caused by left ventricular myocardial function in the various internal and external factors,may ultimately leading to arrhythmia, heart failure, and even the occurrence of sudden cardiac death.Inflammation, myocardial calcium circulatory disorder and profibrotic cytokine release are three important aspects leading to ventricular remodeling, protein kinase C ( PKC) through the regulation of inflammation, calcium ion and fibrosis factor can inhibit the ventricular remodeling, and prevention of sudden death.This article want to clarify the regulation mechanism of PKC, provide a potential therapeutic target for reversing ventricular remodeling.
