Acute toxicity and long-term toxicity study on Chuanping dropping pills
10.13699/j.cnki.1001-6821.2015.15.021
- VernacularTitle:喘平滴丸对Beagle犬的急性毒性和长期毒性实验研究
- Author:
Xiang-E LU
1
;
Ye-Zhi GUAN
;
Qi-Yue GUO
;
Sheng-Shan ZHU
Author Information
1. 广东药学院 中药开发研究所
- Keywords:
Chuanping dropping pills;
acute toxicity;
long -term toxicity
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1536-1538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the acute toxicity and long -term toxicity induced by Chuanping dropping pills in beagle dogs.Methods Acute toxicity test:it was used by the approximate lethal dose on Beagle dogs.Observational index included general clinical observation, weight, ingestion capacity, blood pressure, electrocardiogram, urinalysis, blood test, blood biochemical examination and pathological examination.Long-term toxicity test:Chuanping dropping pills with 0.13, 0.40, 1.19 g · kg-1 · d-1 and the hollow capsules control group in Beagle dogs were lavaged.Observational index included general physiological indices, blood test,blood biochemical examination, urinalysis, electrocardiogram, blood pressure, eye test and pathological examination.Results The approxi-mate lethal dose in beagle dogs lavaged by Chuanping dropping pills was more than 54.79 g · kg-1.Relativel safe dose in Beagle dogs lavaged by Chuanping dropping pills after 90 days was below 0.40 g · kg-1 · d-1.Conclusion Clinical dose of Chuanping dropping pills was safe and reliable.
