Pharmacokinetic study of amlodipine besylate and folic acid tablet in Chinese healthy volunteers
10.13699/j.cnki.1001-6821.2015.15.013
- VernacularTitle:苯磺酸氨氯地平叶酸片在健康人体药代动力学研究
- Author:
Yan LIANG
1
;
Xia ZHAO
;
Jun-Yu XU
;
Xiao LIU
;
Shuo-Han TIAN
;
Jing-Zi LI
;
Yi-Min CUI
Author Information
1. 北京大学第一医院 药剂科
- Keywords:
amlodipine besylate and folic acid tablet;
pharmacokinetic;
LC-MS/MS
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1509-1511,1515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of amlodipine besylate and folic acid tablet in Chinese healthy volunteers.Methods A single administration of two tests and one reference formulation was given to 24 healthy volunteers by oral according to a self -control, three periods, Latin square design study.The concentrations of amlodipine were determined by LC-MS/MS method.Results The main pharma-cokinetic parameters of amlodipine were as follows: AUC0-t were (115.30 ±28.12),(119.42 ±32.80),(113.19 ±27.08) ng · mL-1 · h;Cmax were (2.59 ±0.60), (2.59 ±0.50), (2.56 ±0.59) ng· mL-1;t1/2 were(38.90 ±9.27), (33.85 ±11.31),(40.66 ±7.05) h for two test and one reference formulation, respectively.Conclusion There is no significant difference between the main pharmacokinetic parameters of three formulations.
