Clinical efficacy and safety of lamotrigine adjunctive therapy for vascular cognitive impairment
10.13699/j.cnki.1001-6821.2015.15.006
- VernacularTitle:拉莫三嗪辅助治疗血管性认知障碍的临床疗效及安全性评价
- Author:
Ye-Hua HU
1
;
Ren-Bin LIU
Author Information
1. 金华中心医院 神经内科
- Keywords:
lamotrigine;
vascular cognitive impairment;
event-related potentials
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1487-1490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of lamotrigine adjunctive therapy for vascular cognitive impairment.Methods Ninety -eight vascular cognitive impairment patients were divided into treatment group and control group, each group was 49 patients.In treatment group, every patients were received lamotrigine 50 mg· d-1 in the start dose, and increased to 100-200 mg· d-1 within four weeks.In control group, every patient was received lithium carbonate 500 mg· d-1 in the start dose, and increased to 1000-2000 mg· d-1 within four weeks.All patients were given eight weeks of treatment.Observed the efficacy, Bech -Rafaelsen mania rating scale (BRMS) and clinical global impression-severity of illness (CGI-SI) score changes, P300 and N400 latency changes and adverse reactions.Results The response rates in the treatment group and the control group were 95.92% and 81.63% respectively that the treatment group had significantly higher efficiency ( P<0.05 ).After treatment, the BRMS and CGI-SI scores were showing clear downward trend with a significant difference compared pre-treatment in the two groups( P<0.05 ) , and the the BRMS and CGI-SI scores in the treatment group were significantly lower than the control group after treatment ( P <0.05 ).After treatment, the P300 and N400 latencies were significantly shorter, while the volatility were increased significantly, with were significant differences compared pre-treatment ( P<0.05 ) , while the P300 and N400 latency and amplitude in the treatment group compared with the control group were statistical difference significance ( P<0.05 ).During the treatment, there were two patients were rash, one patient was dizziness and one patient was nausea in the treatment group; there were one patient was dizziness, one patient was nausea, one patient was lethargy.Conclusion Lamotrigine adjunctive therapy vascular cognitive impairment can effectively alleviate the condition and manic conditions, improve time-related potentials, thereby it is contributing to improve the overall clinical efficacy and safety.
