Clinical efficacy and safety analysis of ibutilide and propafenone in the treatment of patients with atrial fibrillation
10.13699/j.cnki.1001-6821.2015.15.002
- VernacularTitle:依布利特对比普罗帕酮转复心房颤动的临床疗效及安全性评价
- Author:
Dong WANG
1
;
Kuan WANG
;
Xin-Ping DU
Author Information
1. 天津市第五中心医院 心内科
- Keywords:
ibutilide;
propafenone;
atrial fibrillation;
cardioversion;
adverse reaction
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1475-1476,1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of ibutilide and propafenone in the treatment of patients with atrial fibrilla-tion.Methods A total of 66 patients with atrial fibrillation were included in this study.Of the recruited 66 subjects, 31 cases ( experiment group ) received ibutilide 1 mg by intravenous injection within 10 min and other 35 cases ( control group) received propafenone 70 mg by intravenous injection within 10 min.The treatment procedure were done again if the atrial fibrillation still existed after administration.The successful rate and adverse reactions were recorded in the two groups.Results The successful rate was 74.2% in experiment group and 51.4%in control group with statistical difference ( P<0.05 ).The median time of cardioversion was 20.5 min for experiment group and 25.2 min in control group with significant difference ( P<0.05 ).The rate of adverse reactions were 29.0% and 25.7% in the treatment and control group, respectively without statistical difference ( P >0.05 ).Conclusion The successful rate of ibutilide in the treatment of patients with atrial fibrillation is relative higher with short period of time for success.
