Effects of bisoprolol on neuroendocrine hormones in patients with heart failure with preserved left ventricular ejection fraction
10.13699/j.cnki.1001-6821.2015.15.001
- VernacularTitle:比索洛尔对左心室射血分数保留的心力衰竭患者神经内分泌因子的影响
- Author:
Yu-Zhi ZHEN
1
;
Yan-Dong DENG
;
Li-Zhuo LI
;
Yin-Ge ZHAN
;
Chao LIU
;
Gang LIU
;
Kun-Shen LIU
Author Information
1. 河北医科大学 第一医院
- Keywords:
bisoprolol;
heart failure with preserved left ventricular ejection fraction;
neuroendocrine hormones;
leptin;
chromogranin A
- From:
The Chinese Journal of Clinical Pharmacology
2015;(15):1471-1474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of bisoprolol adding to the conventional therapy on neuroendocrine hormones in patients with heart failure with preserved left ventricular ejection fraction ( HFPEF ) .Methods Fifty-one patients with HFPEF were randomly assigned into two groups: control group ( n =25 ) and trial group ( n =26 ).The control group was treated with angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonist and aldosterone receptor antagonists, diuretics and other drugs combination therapy.The trial group was the control group plus bisoprolol 5 -10 mg · d-1 .Each group was two weeks.The levels of brain natriuretic peptide ( BNP ) , atrial natriuretic peptide ( ANP ) , leptin, chromogranin A ( CGA ) , interleukin -6 ( IL-6 ) , thromboxane B2 ( TXB2 ) , tumor necrosis factor -α( TNF-α) , endothelin ( ET ) , hypersensitive C-reactive protein ( hs-CRP) were observed fourteen days before and after the treatments, and the incidence rate of adverse drug reactions.Results The total efficiency of the trial group was 88.46%significantly higher than 60.00%in the control group(P<0.05).The levels of plasma BNP, ANP, leptin, CGA, ET, hs-CRP were significantly decreased in the trial group ( P<0.05 ) after treatment.The levels of plasma BNP, ANP, Leptin, CGA, hs-CRP were significantly decreased in the control group ( P<0.05) after treatment.The levels of BNP, leptin, CGA, ET, hs-CRP lower in trial group than in the control group ( P<0.05 ).The incidence rate of adverse drug reactions were not statistical difference between the two groups ( P>0.05).Conclusion Bisoprolol adding to the convertional therapy can significantly improve the heart function of patients with HFPEF and can lead to more decrease of BNP, leptin, CGA, ET, hs -CRP than the conventional therapy.
