Influence of glutamate on the pathogenesis of motion sickness and relative drugs research
10.13699/j.cnki.1001-6821.2015.14.032
- VernacularTitle:谷氨酸在晕动病发病机制中的作用及相关药物研究
- Author:
LüDa-na
1
;
Shu-Yu LIN
;
Yang HUANG
;
Chang-Yun YANG
Author Information
1. 解放军第 180 医院 药学科
- Keywords:
glutamate;
motion sickness;
excitatory neurotoxicity;
ion channel antagonist;
glutamate receptor antagonist
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1462-1465
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is not only the major excitatory neurotransmitter in the central nervous system of human and mammalian animals but also participates the synaptic transmission of peripheral sensory system.How-ever, overstimulation of glutamate receptors by excessive glutamate leads to glutamate excitotoxicity.This review discusses the neurotransmission of glutamate in the vestibular end organs and the excitotoxicity by glutamate on them in motion sickness as well as the antimotion sickness drugs asso-ciated with glutamate neurotransmission.
